USF-LVHN SELECT
Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology.
Publication/Presentation Date
1-1-2022
Abstract
INTRODUCTION: The impact of hepatorenal function on plasma biomarkers of neuropathology is unknown. Herein, we measured several plasma biomarkers in patients with cirrhosis.
METHODS: Plasma phosphorylated tau (p-tau181), neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), total tau (t-tau), and ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) were measured in 135 adults with cirrhosis and 22 healthy controls using Simoa. Within cirrhosis, associations between biomarkers and hepatorenal function were explored using linear regression.
RESULTS: p-tau181, NfL, t-tau, and UCHL1 were increased 2- to 4-fold in cirrhosis, whereas GFAP was not increased. Within cirrhosis, creatinine moderately correlated with p-tau181 (
CONCLUSIONS: Elevated p-tau181, NfL, and t-tau in cirrhosis were associated with renal impairment and hypoalbuminemia, suggesting that hepatorenal function may be important when interpreting plasma biomarkers of neuropathology.
Volume
14
Issue
1
First Page
12321
Last Page
12321
ISSN
2352-8729
Published In/Presented At
Berry, K., Asken, B. M., Grab, J. D., Chan, B., Lario Lago, A., Wong, R., Seetharaman, S., LaHue, S. C., Possin, K. L., Rojas, J. C., Kramer, J. H., Boxer, A. L., Lai, J. C., & VandeVrede, L. (2022). Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology. Alzheimer's & dementia (Amsterdam, Netherlands), 14(1), e12321. https://doi.org/10.1002/dad2.12321
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
35845260
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article