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USF-LVHN SELECT
Clinical Outcomes After Idecabtagene Vicleucel in Older Multiple Myeloma Patients: A Multicenter Real-world Experience.
Publication/Presentation Date
7-23-2024
Abstract
The safety and efficacy of CAR T-cell therapy is not well described in older patients, a population that has higher frailty and co-morbidities. In this multicenter retrospective study, we evaluated clinical outcomes along with frailty and geriatric characteristics such as comorbidities, polypharmacy, falls, neuropathy, organ dysfunction, and performance status in younger (<65 >years) versus older (≥65 years) patients who received commercial idecabtagene vicleucel (ide-cel). A total of 156 patients (n=75, ≥65 years) were infused with ide-cel by data cut-off. In older patients (median age: 69 years, range: 65-83 years; 66.7% frail; 77.3% did not meet KarMMa eligibility criteria), with a median follow-up duration of 14.2 months, best overall response rate (ORR) was 86.7%, which was comparable to pivotal KarMMa study results (ORR: 73%). Median progression-free survival (PFS) and overall survival (OS) in older patients were 9.1 months and 26.5 months, respectively. Grade 3 or higher cytokine-release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) were observed in 1% and 4% of older patients, respectively. Compared to younger patients, the older patients had significantly higher prevalence of frailty, geriatric characteristics such as polypharmacy (5+ drugs; 97%), 4+ comorbidities (69%), and organ dysfunction (35%) (p
ISSN
2473-9537
Published In/Presented At
Kalariya, N., Hildebrandt, M. A. T., Hansen, D. K., Sidana, S., Khouri, J., Ferreri, C. J., Doyle, W. N., Jr, Castaneda Puglianini, O. A., Freeman, C. L., Hovanky, V., Hosoya, H., Shune, L., & Patel, K. K. (2024). Clinical Outcomes After Idecabtagene Vicleucel in Older Multiple Myeloma Patients: A Multicenter Real-world Experience. Blood advances, bloodadvances.2024013540. Advance online publication. https://doi.org/10.1182/bloodadvances.2024013540
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
39042903
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article