USF-LVHN SELECT
The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment.
Publication/Presentation Date
10-16-2024
Abstract
BACKGROUND: Genetics may influence symptoms experienced by breast cancer survivors (BCS) by moderating the effects of stress-reducing interventions, including the Mindfulness-Based Stress Reduction (MBSR(BC)) program, to reduce symptom severity. As part of a larger clinical trial, the aim of this study was to evaluate genetic variants as moderators of MBSR(BC) on improvements among BCS in cognitive functioning and symptoms.
METHODS: BCS (
RESULTS: Results showed MBSR(BC) participants experienced significantly greater benefits in cognitive functioning, however, the level of benefit varied based on one's genetic profile. Effects sizes, consistency across similar measures were investigated. Among 22 candidate SNPs, rs4680 in COMT, rs1800497 in ANKK1, and rs6277 in DRD2 demonstrated the strongest, most consistent positive effects in moderating MBSR(BC)'s impact on cognitive outcomes.
CONCLUSIONS: Although the effects were small, this translational research may potentially identify BCS with genotypes that would be most influenced by the MBSR(BC) program. These results may be used to develop personalized intervention programs tailored to the genetic profile of each breast cancer survivor who received chemotherapy or chemotherapy and radiation.
TRIAL REGISTRATION: ClinicalTrials.gov, https://www.ClinicalTrials.gov Registration Number: NCT02786797.
First Page
10998004241289629
Last Page
10998004241289629
ISSN
1552-4175
Published In/Presented At
Park, J. Y., Lengacher, C. A., Rodriguez, C. S., Meng, H., Kip, K. E., Morgan, S., Joshi, A., Hueluer, G., Wang, J. R., Tinsley, S., Cox, C., Kiluk, J., Donovan, K. A., Moscoso, M., Bornstein, E., Lucas, J. M., Fonseca, T., Krothapalli, M., Padgett, L. S., Nidamanur, S., … Reich, R. R. (2024). The Moderating Role of Genetics on the Effectiveness of the Mindfulness-Based Stress Reduction for Breast Cancer (MBSR(BC)) Program on Cognitive Impairment. Biological research for nursing, 10998004241289629. Advance online publication. https://doi.org/10.1177/10998004241289629
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
39413359
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article