USF-LVHN SELECT
Clinical utility of maximum blink interval measured by smartphone application DryEyeRhythm to support dry eye disease diagnosis.
Publication/Presentation Date
8-21-2023
Abstract
The coronavirus disease (COVID-19) pandemic has emphasized the paucity of non-contact and non-invasive methods for the objective evaluation of dry eye disease (DED). However, robust evidence to support the implementation of mHealth- and app-based biometrics for clinical use is lacking. This study aimed to evaluate the reliability and validity of app-based maximum blink interval (MBI) measurements using DryEyeRhythm and equivalent traditional techniques in providing an accessible and convenient diagnosis. In this single-center, prospective, cross-sectional, observational study, 83 participants, including 57 with DED, had measurements recorded including slit-lamp-based, app-based, and visually confirmed MBI. Internal consistency and reliability were assessed using Cronbach's alpha and intraclass correlation coefficients. Discriminant and concurrent validity were assessed by comparing the MBIs from the DED and non-DED groups and Pearson's tests for each platform pair. Bland-Altman analysis was performed to assess the agreement between platforms. App-based MBI showed good Cronbach's alpha coefficient, intraclass correlation coefficient, and Pearson correlation coefficient values, compared with visually confirmed MBI. The DED group had significantly shorter app-based MBIs, compared with the non-DED group. Bland-Altman analysis revealed minimal biases between the app-based and visually confirmed MBIs. Our findings indicate that DryEyeRhythm is a reliable and valid tool that can be used for non-invasive and non-contact collection of MBI measurements, which can assist in accessible DED detection and management.
Volume
13
Issue
1
First Page
13583
Last Page
13583
ISSN
2045-2322
Published In/Presented At
Fujio, K., Nagino, K., Huang, T., Sung, J., Akasaki, Y., Okumura, Y., Midorikawa-Inomata, A., Fujimoto, K., Eguchi, A., Miura, M., Hurramhon, S., Yee, A., Hirosawa, K., Ohno, M., Morooka, Y., Murakami, A., Kobayashi, H., & Inomata, T. (2023). Clinical utility of maximum blink interval measured by smartphone application DryEyeRhythm to support dry eye disease diagnosis. Scientific reports, 13(1), 13583. https://doi.org/10.1038/s41598-023-40968-y
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
37604900
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article