USF-LVHN SELECT
Amplification of
Publication/Presentation Date
10-1-2024
Abstract
PURPOSE: In lung squamous cell carcinoma (LUSC), Black patients show significantly higher incidence and lower overall survival than White patients. Although socioeconomic factors likely contribute to this survival disparity, genomic factors have yet to be elucidated in LUSC.
METHODS: Using 416 LUSC tumor samples in the Cancer Genome Atlas (TCGA), we assessed genomic and transcriptomic profiles by ancestry. We replicated our analyses in pan-cancer data from TCGA, the American Association of Cancer Research (AACR) Genomics Evidence Neoplasia Information Exchange (GENIE), and Columbia University Medical Center.
RESULTS: We found increased
CONCLUSION: Together, our data suggest that ancestry may influence amplification of not only
Volume
8
First Page
2400223
Last Page
2400223
ISSN
2473-4284
Published In/Presented At
Jain, S., Bai, X., Mallick, S., Kinghorn, B., May, B., Yao, A. G., Allen-Gipson, D., Zhang, X., Henick, B. S., Momen-Heravi, F., Carrot-Zhang, J., & Taylor, A. M. (2024). Amplification of MYC and Its Enhancer Correlates With Genetic Ancestry in Lung Squamous Cell Carcinoma. JCO precision oncology, 8, e2400223. https://doi.org/10.1200/PO.24.00223
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
39447097
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article