USF-LVHN SELECT
Emergence of ST3390: A non-pigmented HA-MRSA clone with enhanced virulence.
Publication/Presentation Date
3-18-2025
Abstract
BACKGROUND: One of the most successful and widely-distributed hospital-associated lineages of MRSA is CC5. These strains are known from widespread antibiotic resistance, but less severe disease than CA-MRSA counterparts. Recently, CC5 descendant lineages have appeared globally with hypervirulent properties.
METHODS: Herein we use genomic analyses to study the epidemiology of a rare CC5 MRSA sequence type, ST3390, circulating within Tampa General Hospital (TGH). We employ genetic tools alongside
RESULTS: To date, there have only been 50 recorded instances of infection caused by ST3390 globally, with 36 of those occurring at TGH. Genomic analysis of strains identified numerous
CONCLUSIONS: This is the first study to characterize the pathogenicity and genomic architecture of the rare MRSA lineage ST3390. Our work provides a deeper understanding of the clonal expansion of CC5, and the wider diversification of
ISSN
2692-8205
Published In/Presented At
Felton, E. A., Jobson, M. E., Virgillio, A. M., Alvior, J., Cella, E., Lima, A., Becker, D., Silbert, S., Azarian, T., Kim, K., & Shaw, L. N. (2025). Emergence of ST3390: A non-pigmented HA-MRSA clone with enhanced virulence. bioRxiv : the preprint server for biology, 2025.03.18.643911. https://doi.org/10.1101/2025.03.18.643911
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
40166326
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article
