USF-LVHN SELECT
Decoding functional hematopoietic progenitor cells in the adult human lung.
Publication/Presentation Date
2-27-2025
Abstract
While the bone marrow is the main site of blood cell production in adults, rare pools of hematopoietic stem and progenitor cells have been found in extramedullary organs. In mice, we have previously shown that the lungs contain hematopoietic progenitor cells and is a site of platelet production. Here, in the adult human lung, we show that functional hematopoietic precursors reside in the extravascular spaces with a frequency similar to the bone marrow, and are capable of proliferation and engraftment in mice. The gene signature of pulmonary and medullary CD34+ hematopoietic progenitors indicates greater baseline activation of immune, megakaryocyte/platelet and erythroid-related pathways in lung progenitors. Spatial transcriptomics mapped blood progenitors in the lung to an alveolar interstitium niche with only a few cells identified in an intravascular location. In human blood samples collected for stem cell transplantation, CD34+ cells with a lung signature enriched the mobilized pool of hematopoietic stem cells. These results identify the lung as a pool for uniquely programmed blood stem and progenitor cells with the potential to support hematopoiesis in humans.
ISSN
1528-0020
Published In/Presented At
Conrad, C., Magnen, M., Tsui, J., Wismer, H. J., Naser, M., Venkataramani, U., Samad, B., Cleary, S. J., Qiu, L., Tian, J. J., De Giovanni, M., Mende, N., Leavitt, A. D., Passegue, E., Laurenti, E., PhD, Combes, A. J., & Looney, M. R. (2025). Decoding functional hematopoietic progenitor cells in the adult human lung. Blood, blood.2024027884. Advance online publication. https://doi.org/10.1182/blood.2024027884
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
40014797
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article
