USF-LVHN SELECT
Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma.
Publication/Presentation Date
1-1-2024
Abstract
INTRODUCTION: Cutaneous T-cell lymphoma (CTCL) is closely associated with the host microbiome. While recent evidence suggests that shifts in specific bacterial taxa are associated with response to UV-B, a form of non-ionizing radiation, the impact of ionizing radiation (IR) has not been investigated.
METHODS: 16S rRNA and
RESULTS: Radiation exposure increased CTCL skin α-diversity to levels approximating HC. TSEBT appeared to carry the greatest effect compared to local IR. Both α and β-diversity differed significantly post versus pre-IR for TSEBT, but not for local IR. IR was associated with decreases in known pathogenic bacteria such as
DISCUSSION: IR not only eliminates CTCL lesions via induction of apoptosis, but also facilitates skin barrier restoration and recolonization of bacterial taxa associated with a healthy skin microbiome. Local IR does not have as strong an effect on the skin microbiome as TSEBT. As skin microbiota act as immunomodulators with local and potentially systemic influence, TSEBT may also improve CTCL lesions via global effects on the skin microbiome. Future larger-scale studies are required to fully elucidate the relationship between cutaneous microbes and IR treatment in CTCL.
Volume
15
First Page
1520214
Last Page
1520214
ISSN
1664-3224
Published In/Presented At
Chrisman, L. P., Pang, Y., Hooper, M. J., Rajeev-Kumar, G., Nguyen, W. Q., Green, S. J., Seed, P. C., Liang, H., Mittal, B. B., Hasan, Y., Guitart, J., Weichselbaum, R. R., Burns, M. B., & Zhou, X. A. (2024). Ionizing radiation improves skin bacterial dysbiosis in cutaneous T-cell lymphoma. Frontiers in immunology, 15, 1520214. https://doi.org/10.3389/fimmu.2024.1520214
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
39776918
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article
