USF-LVHN SELECT
Is Site of Radiation Therapy Associated With Pathologic Complete Response in Patients With Locally Advanced Esophageal Cancer?
Publication/Presentation Date
1-1-2025
Abstract
IntroductionNeoadjuvant chemoradiation (CRT) is commonly used for esophageal cancer (EC), with pathologic complete response (pCR) linked to improved prognosis. pCR rates range from 25%-30% for adenocarcinoma to 50% for squamous cell carcinoma (SCC). High-volume centers (HVCs) often yield favorable outcomes across various cancers. This study examines whether CRT delivery at an HVC impacts pCR and ypN0 rates in EC patients undergoing esophagectomy.MethodsIn this retrospective cohort analysis, we identified patients with clinical stage T2+/N+ EC who received neoadjuvant CRT and esophagectomy from a prospectively maintained database (1996-2019). CRT was delivered at the HVC or a community center (CC), while all surgeries occurred at the HVC. Primary outcomes were pCR and ypN0.ResultsAmong 708 patients, median age was 65 years, with 83.6% male and 95.3% white. Most had adenocarcinoma (87.9%) in the distal esophagus or gastroesophageal junction. CRT was delivered at CCs in 64.8% and at HVC in 35.2%. Radiation dose was higher at the HVC (mean 5195 vs 4944 cGy,
Volume
32
First Page
10732748251382635
Last Page
10732748251382635
ISSN
1526-2359
Published In/Presented At
Singh, P., Choo, S., Adams, J., Adams, M., Lima Pereira, A. A., Baldonado, J. J. A., Fontaine, J. P., Sandoval, M. L., Frakes, J. M., Pimiento, J. M., Hoffe, S. E., & Sinnamon, A. J. (2025). Is Site of Radiation Therapy Associated With Pathologic Complete Response in Patients With Locally Advanced Esophageal Cancer?. Cancer control : journal of the Moffitt Cancer Center, 32, 10732748251382635. https://doi.org/10.1177/10732748251382635
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
40992780
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article