USF-LVHN SELECT
Genomic and Phenotypic Characterization of Mupirocin-resistant
Publication/Presentation Date
7-1-2025
Abstract
BACKGROUND: Colonization with
METHODS: We characterized oxacillin and mupirocin susceptibility amongst 384
RESULTS: Mupirocin resistance (MupR) was nearly exclusively present in MRSA strains (103/106, 97.1% of MupR; 103/299, 34.4% of MRSA). Although our hospital protocol for decolonization shifted to povidone iodine in the post-COVID period, the overall prevalence of MupR did not change in pre-COVID and post-COVID samples (28.9% vs 26%). Genotype correlated with antibiotic susceptibility with low-level MupR, linked to mutations in
CONCLUSIONS: Mupirocin resistance was prevalent in our hospital MRSA strains. We also found evidence for emergence and persistence of ST3390 MRSA-MupR strains in Florida.
Volume
12
Issue
7
First Page
374
Last Page
374
ISSN
2328-8957
Published In/Presented At
Virgillio, A. M., Felton, E. A., Jackson, J. K., Kennedy, S. J., Becker, D. N., Lima, A., Atrubin, K., Cella, E., Azarian, T., Silbert, S., Shaw, L. N., & Kim, K. (2025). Genomic and Phenotypic Characterization of Mupirocin-resistant Staphylococcus aureus Clinical Isolates. Open forum infectious diseases, 12(7), ofaf374. https://doi.org/10.1093/ofid/ofaf374
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
40698033
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article