USF-LVHN SELECT

Examining the safety of dermatological and surgical procedures in patients undergoing systemic isotretinoin therapy: An updated review.

Publication/Presentation Date

6-30-2026

Abstract

BACKGROUND: Isotretinoin is a highly effective treatment for severe nodulocystic acne. Concerns regarding impaired wound healing and an increased risk of hypertrophic or keloid scarring have historically led to recommendations that cutaneous procedures be delayed for at least 6 months after isotretinoin therapy. Recent evidence has challenged the necessity of this practice.

OBJECTIVE: To review the current literature evaluating the effects of isotretinoin on skin and wound healing in patients undergoing dermatologic, cosmetic, and surgical procedures.

METHODS: A comprehensive review of published studies examining wound healing outcomes, scarring, and procedural complications in patients receiving concurrent or recent isotretinoin therapy was performed. Evidence was evaluated across multiple procedure categories, including dermabrasion, laser treatments, chemical peels, microneedling, cutaneous surgery, ophthalmic surgery, and other surgical interventions.

RESULTS: Most contemporary studies reported normal wound healing and a low incidence of adverse scarring in patients undergoing procedures during or shortly after isotretinoin treatment. Evidence supporting a mandatory 6-month discontinuation period was limited and was largely based on older case reports and small case series. Studies evaluating laser therapies, chemical peels, microneedling, and various surgical procedures generally demonstrated favorable outcomes without increased rates of hypertrophic scarring or keloid formation. Several investigations also reported improved acne severity, acne scarring, and patient satisfaction when isotretinoin was combined with procedural interventions.

CONCLUSION: Current evidence suggests that the risk of abnormal wound healing or scarring associated with concurrent or recent isotretinoin use is minimal for most dermatologic and surgical procedures. Routine postponement of procedures solely because of isotretinoin therapy may be unnecessary in many patients. Further prospective studies, particularly in individuals with darker skin phototypes and those predisposed to abnormal scar formation, are needed to refine clinical recommendations.

Volume

32

Issue

3

ISSN

1087-2108

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

42522519

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article

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