USF-LVHN SELECT
TRBV and TRBJ usage, when paired with specific HLA alleles, associates with distinct head and neck cancer survival rates.
Publication/Presentation Date
12-1-2020
Abstract
Common or dominant, T-cell receptor (TCR), V and J usage, in combination with particular human leukocyte antigen (HLA) alleles, has been associated with differing outcomes in viral infections, autoimmunity, and more recently, in cancer. Cervical cancer in particular represents the most dramatic series of distinctions of outcomes associated with differing combinations of dominant V or J usage and HLA alleles, possibly because of the strong association of cervical cancer with human papilloma virus (HPV), in turn leading to a likely molecular consistency in the mechanism of HPV antigen presentation. Thus, we considered assessing TRB V and J usage, HLA allele combinations, for their associations with survival rates and related data, in the cancer genome atlas head and neck cancer dataset. We obtained the TRB VDJ recombination reads from both the blood and tumor exome files and determined the V and J identities. We then established case ID (patient) subsets of V or J usage, HLA alleles, and determined, for example, that the TRBJ2-7, HLA-B*40:01 combination was associated with a better disease free survival rate than were either the TRBJ1-3, HLA-DPB1*03:01 or the TRBJ2-1, HLA-DPB1*02:01 combinations. Furthermore, these analyses led to the conclusion that TRBJ1-5 usage, and the HLA-C*08:02 and HLA-DRB1*03:01 alleles, had independent associations with distinct overall survival rates. In sum, the results suggest that dominant V or J usage, HLA allele combinations, and in certain cases, dominant V or J usage independently of HLA, could be useful in prognosis and in guiding immunotherapies.
Volume
81
Issue
12
First Page
692
Last Page
696
ISSN
1879-1166
Published In/Presented At
Arndt, M. F., Koohestani, D. M., Chobrutskiy, B. I., Mihyu, M. M., Diaz, M., Gozlan, E. C., Yeagley, M., Zaman, S., Roca, A. M., & Blanck, G. (2020). TRBV and TRBJ usage, when paired with specific HLA alleles, associates with distinct head and neck cancer survival rates. Human immunology, 81(12), 692–696. https://doi.org/10.1016/j.humimm.2020.08.007
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
32950267
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article