Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.

Authors

Antonio Di Zazzo
Sang-Mok Lee
Jaemyoung Sung, Lehigh Valley Health NetworkFollow
Matteo Niutta
Marco Coassin
Alireza Mashaghi
Takenori Inomata

Publication/Presentation Date

2-21-2020

Abstract

Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic decision-making in corneal transplantation. Valuable insights into the clinically observed heterogeneity of host responses to corneal grafts have emerged from multidisciplinary approaches, including genomics analyses, mechanical studies, immunobiology, and theoretical modeling. Here, we review the emerging concepts, tools, and new biomarkers that may allow for the prediction of graft survival.

Volume

9

Issue

2

ISSN

2077-0383

Published In/Presented At

Di Zazzo, A., Lee, S. M., Sung, J., Niutta, M., Coassin, M., Mashaghi, A., & Inomata, T. (2020). Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology. Journal of clinical medicine, 9(2), 586. https://doi.org/10.3390/jcm9020586

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

32098130

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article