Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology.
Corneal grafts interact with their hosts via complex immunobiological processes that sometimes lead to graft failure. Prediction of graft failure is often a tedious task due to the genetic and nongenetic heterogeneity of patients. As in other areas of medicine, a reliable prediction method would impact therapeutic decision-making in corneal transplantation. Valuable insights into the clinically observed heterogeneity of host responses to corneal grafts have emerged from multidisciplinary approaches, including genomics analyses, mechanical studies, immunobiology, and theoretical modeling. Here, we review the emerging concepts, tools, and new biomarkers that may allow for the prediction of graft survival.
Published In/Presented At
Di Zazzo, A., Lee, S. M., Sung, J., Niutta, M., Coassin, M., Mashaghi, A., & Inomata, T. (2020). Variable Responses to Corneal Grafts: Insights from Immunology and Systems Biology. Journal of clinical medicine, 9(2), 586. https://doi.org/10.3390/jcm9020586
Medical Education | Medicine and Health Sciences
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students