USF-LVHN SELECT
Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis.
Publication/Presentation Date
11-1-2022
Abstract
We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson's disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian-Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.
Volume
12
Issue
1
First Page
18348
Last Page
18348
ISSN
2045-2322
Published In/Presented At
Nagino, K., Sung, J., Oyama, G., Hayano, M., Hattori, N., Okumura, Y., Fujio, K., Akasaki, Y., Huang, T., Midorikawa-Inomata, A., Fujimoto, K., Eguchi, A., Hurramhon, S., Miura, M., Ohno, M., Hirosawa, K., Morooka, Y., Murakami, A., Kobayashi, H., & Inomata, T. (2022). Prevalence and characteristics of dry eye disease in Parkinson's disease: a systematic review and meta-analysis. Scientific reports, 12(1), 18348. https://doi.org/10.1038/s41598-022-22037-y
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
36319814
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article