Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities.
We assessed the T-cell receptor gamma (TRG) recombination reads from the cancer genome atlas melanoma tumor exome files and the TRG recombination reads from an independent, melanoma exome file dataset, from the Moffitt Cancer Center. TRG complementarity determining region-3 (CDR3) amino acid (AA) sequences were assessed for chemical complementarity to cancer testis antigens, with such complementarity for FAM133A and CRISP2 associated with better survival probabilities for both datasets. These results, along with related TRG CDR3 AA chemical feature assessments provided in this report, have indicated opportunities for melanoma patient stratifications based on the recovery of TRG recombination reads from both tumor and blood samples, and the results may point towards novel, effective melanoma antigens.
Published In/Presented At
Agnila, D. R. L., Huda, T. I., Eakins, R. A., Patel, D. N., Hsiang, M., Chobrutskiy, A., Chobrutskiy, B. I., & Blanck, G. (2023). Chemical features of melanoma tumor resident TRG CDR3s associated with better survival probabilities. Melanoma research, 10.1097/CMR.0000000000000899. Advance online publication. https://doi.org/10.1097/CMR.0000000000000899
Medical Education | Medicine and Health Sciences
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students