Bilateral Hypotony Maculopathy Associated With Ipilimumab and Nivolumab Therapy Unresponsive to Corticosteroid Treatment.

Authors

Abrahim Ahmed, Lehigh Valley Health NetworkFollow
Farhan E Hiya
David A Eichenbaum

Publication/Presentation Date

5-1-2023

Abstract

In rare instances, immunotherapy associated with hypotony and uveitis has been documented. We report the case of a 72-year-old man treated with 2 months of ipilimumab and nivolumab for metastatic melanoma who developed bilateral hypotony maculopathy and serous choroidal detachments without prominent initial uveitis. Despite treatment with topical, periocular, and intraocular corticosteroid injection, hypotony persisted 18 months after immunotherapy cessation. The patient's unresponsiveness to corticosteroids indicates the need to further explore the mechanism behind immune checkpoint inhibitor-associated hypotony. We hypothesize that immunotherapy significantly decreased aqueous humor production through ciliary body inflammation, disruption, or shutdown.

Volume

54

Issue

5

First Page

301

Last Page

304

ISSN

2325-8179

Published In/Presented At

Ahmed, A. A., Hiya, F. E., & Eichenbaum, D. A. (2023). Bilateral Hypotony Maculopathy Associated With Ipilimumab and Nivolumab Therapy Unresponsive to Corticosteroid Treatment. Ophthalmic surgery, lasers & imaging retina, 54(5), 301–304. https://doi.org/10.3928/23258160-20230405-01

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

37078857

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article