USF-LVHN SELECT
The Role of Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease.
Publication/Presentation Date
7-26-2022
Abstract
Despite the reality that a death from cerebrovascular accident occurs every 3.5 min in the United States, there are few therapeutic options which are typically limited to a narrow window of opportunity in time for damage mitigation and recovery. Novel therapies have targeted pathological processes secondary to the initial insult, such as oxidative damage and peripheral inflammation. One of the greatest challenges to therapy is the frequently permanent damage within the CNS, attributed to a lack of sufficient neurogenesis. Thus, recent use of cell-based therapies for stroke have shown promising results. Unfortunately, stroke-induced inflammatory and oxidative damage limit the therapeutic potential of these stem cells. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been implicated in endogenous antioxidant and anti-inflammatory activity, thus presenting an attractive target for novel therapeutics to enhance stem cell therapy and promote neurogenesis. This review assesses the current literature on the concomitant use of stem cell therapy and Nrf2 targeting via pharmaceutical and natural agents, highlighting the need to elucidate both upstream and downstream pathways in optimizing Nrf2 treatments in the setting of cerebrovascular disease.
Volume
11
Issue
8
ISSN
2076-3921
Published In/Presented At
Gordon, J., Lockard, G., Monsour, M., Alayli, A., & Borlongan, C. V. (2022). The Role of Concomitant Nrf2 Targeting and Stem Cell Therapy in Cerebrovascular Disease. Antioxidants (Basel, Switzerland), 11(8), 1447. https://doi.org/10.3390/antiox11081447
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
35892653
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article