Mitochondria in Cell-Based Therapy for Stroke.

Authors

Molly Monsour
Jonah Gordon
Gavin Lockard, Lehigh Valley Health NetworkFollow
Adam Alayli, Lehigh Valley Health NetworkFollow
Cesar V Borlongan

Publication/Presentation Date

1-12-2023

Abstract

Despite a relatively developed understanding of the pathophysiology underlying primary and secondary mechanisms of cell death after ischemic injury, there are few established treatments to improve stroke prognoses. A major contributor to secondary cell death is mitochondrial dysfunction. Recent advancements in cell-based therapies suggest that stem cells may be revolutionary for treating stroke, and the reestablishment of mitochondrial integrity may underlie these therapeutic benefits. In fact, functioning mitochondria are imperative for reducing oxidative damage and neuroinflammation following stroke and reperfusion injury. In this review, we will discuss the role of mitochondria in establishing the anti-oxidative effects of stem cell therapies for stroke.

Volume

12

Issue

1

ISSN

2076-3921

Published In/Presented At

Monsour, M., Gordon, J., Lockard, G., Alayli, A., & Borlongan, C. V. (2023). Mitochondria in Cell-Based Therapy for Stroke. Antioxidants (Basel, Switzerland), 12(1), 178. https://doi.org/10.3390/antiox12010178

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

36671040

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article