Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring.

Authors

Michael Joseph Diaz
Angela Fadil
Giona Kleinberg
Kevin T Root
Lauern Ladehoff, Lehigh Valley Health NetworkFollow
Sai Batchu
Brandon Lucke-Wold

Publication/Presentation Date

1-1-2022

Abstract

OBJECTIVE: The significant metastatic potential of uveal melanoma (UVM) lends to high mortality. Even with successful local tumor treatment, many patients will develop metastatic disease. The present study aims to elucidate the relationship between tumor-infiltrating immune cell (TIIC) diversity and survival to identify potential therapeutic targets and improve UVM prognosis.

METHODS: Bulk deconvolution was used to determine the relative proportions of 22 hematopoietic TIIC from 80 UVM tumor samples. Cytolytic activity (CYT) was determined, and associated survival probabilities were mined using time-to-event data. Nominal

RESULTS: High relative abundance of tumor-infiltrating naïve B cells, resting memory CD4

CONCLUSION: Infiltrating naïve B cells, resting memory CD4

Volume

3

Issue

1

First Page

6

Last Page

11

ISSN

2767-3405

Published In/Presented At

Diaz, M. J., Fadil, A., Kleinberg, G., Root, K. T., Ladehoff, L., Batchu, S., & Lucke-Wold, B. (2022). Omics analysis of uveal melanoma: Leukocyte gene signatures reveal novel survival distinctions and indicate a prognostic role for cytolytic activity scoring. The neuroscience chronicles, 3(1), 6–11.

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

36866123

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article