USF-LVHN SELECT
Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma.
Publication/Presentation Date
7-24-2020
Abstract
Advances in the treatment of Ewing's sarcoma (EWS) are desperately needed, particularly in the case of metastatic disease. A deeper understanding of collateral sensitivity, where the evolution of therapeutic resistance to one drug aligns with sensitivity to another drug, may improve our ability to effectively target this disease. For the first time in a solid tumor, we produced a temporal collateral sensitivity map that demonstrates the evolution of collateral sensitivity and resistance in EWS. We found that the evolution of collateral resistance was predictable with some drugs but had significant variation in response to other drugs. Using this map of temporal collateral sensitivity in EWS, we can see that the path toward collateral sensitivity is not always repeatable, nor is there always a clear trajectory toward resistance or sensitivity. Identifying transcriptomic changes that accompany these states of transient collateral sensitivity could improve treatment planning for patients with EWS.
Volume
23
Issue
7
First Page
101293
Last Page
101293
ISSN
2589-0042
Published In/Presented At
Scarborough, J. A., McClure, E., Anderson, P., Dhawan, A., Durmaz, A., Lessnick, S. L., Hitomi, M., & Scott, J. G. (2020). Identifying States of Collateral Sensitivity during the Evolution of Therapeutic Resistance in Ewing's Sarcoma. iScience, 23(7), 101293. https://doi.org/10.1016/j.isci.2020.101293
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
32623338
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article