Compromised Behavior and Gamma Power During Working Memory in Cognitively Healthy Individuals With Abnormal CSF Amyloid/Tau.

Authors

Roger Rochart, Lehigh Valley Health NetworkFollow
Quanying Liu
Alfred N Fonteh
Michael G Harrington
Xianghong Arakaki

Publication/Presentation Date

1-1-2020

Abstract

Research shows that gamma activity changes in Alzheimer's disease (AD), revealing synaptic pathology and potential therapeutic applications. We aim to explore whether cognitive challenge combined with quantitative EEG (qEEG) can unmask abnormal gamma frequency power in healthy individuals at high risk of developing AD. We analyzed low (30-50 Hz) and high gamma (50-80 Hz) power over six brain regions at EEG sensor level (frontal/central/parietal/left temporal/right temporal/occipital) in a dataset collected from an aging cohort during N-back working memory (WM) testing at two different load conditions (

Volume

12

First Page

574214

Last Page

574214

ISSN

1663-4365

Published In/Presented At

Rochart, R., Liu, Q., Fonteh, A. N., Harrington, M. G., & Arakaki, X. (2020). Compromised Behavior and Gamma Power During Working Memory in Cognitively Healthy Individuals With Abnormal CSF Amyloid/Tau. Frontiers in aging neuroscience, 12, 574214. https://doi.org/10.3389/fnagi.2020.574214

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

33192465

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article