Promising therapeutic potential of tumor suppressor microRNAs for malignant pleural mesothelioma.

Authors

Shivani Dixit
Agnes Y Choi
Anand Singh
Karthik Pittala, Lehigh Valley Health NetworkFollow
Nathan Pruett
Chuong D Hoang

Publication/Presentation Date

1-1-2022

Abstract

Malignant pleural mesothelioma (MPM) is an aggressive and recalcitrant surface neoplasm that defies current multimodality treatments. MicroRNAs (miRNAs) are small noncoding RNAs that epigenetically regulate multiple gene networks and cellular processes. In cancer, miRNA dysregulation is associated with tumorigenesis, with tumor suppressor miRNAs underexpressed or lost, while oncogenic miRNAs are overexpressed. Consequently, miRNAs have emerged as potential therapeutic candidates. Because loss of tumor suppressors predominates the pathophysiology of MPM, re-expressing tumor suppressor miRNAs could be an effective therapeutic strategy. This review highlights the most promising MPM-specific tumor suppressor miRNAs that could be developed into novel therapeutics, the supporting data, and what is known about their molecular mechanism(s).

Volume

8

ISSN

2394-4722

Published In/Presented At

Dixit, S., Choi, A. Y., Singh, A., Pittala, K., Pruett, N., & Hoang, C. D. (2022). Promising therapeutic potential of tumor suppressor microRNAs for malignant pleural mesothelioma. Journal of cancer metastasis and treatment, 8, 47. https://doi.org/10.20517/2394-4722.2022.70

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

37323368

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article