Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit.

Authors

Marianne J Bezaire
Ivan Raikov
Kelly Burk
Dhrumil Vyas
Ivan Soltesz

Publication/Presentation Date

12-23-2016

Abstract

The hippocampal theta rhythm plays important roles in information processing; however, the mechanisms of its generation are not well understood. We developed a data-driven, supercomputer-based, full-scale (1:1) model of the rodent CA1 area and studied its interneurons during theta oscillations. Theta rhythm with phase-locked gamma oscillations and phase-preferential discharges of distinct interneuronal types spontaneously emerged from the isolated CA1 circuit without rhythmic inputs. Perturbation experiments identified parvalbumin-expressing interneurons and neurogliaform cells, as well as interneuronal diversity itself, as important factors in theta generation. These simulations reveal new insights into the spatiotemporal organization of the CA1 circuit during theta oscillations.

Volume

5

ISSN

2050-084X

Published In/Presented At

Bezaire, M. J., Raikov, I., Burk, K., Vyas, D., & Soltesz, I. (2016). Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. eLife, 5, e18566. https://doi.org/10.7554/eLife.18566

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

28009257

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article