Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities.

Authors

Hanchu Xiong
Wenhe Zhao
Ji Wang
Benjamin J Seifer
Chenyang Ye
Yongxia Chen
Yunlu Jia
Cong Chen
Jianguo Shen
Linbo Wang
Xinbing Sui
Jichun Zhou

Publication/Presentation Date

4-11-2017

Abstract

The RNA binding protein Lin28 is best known for the critical role in cell development, recent researches also have implied its oncogenic function in various human cancers, including breast cancer. Specifically, aberrant Lin28 participates in multiple pathological processes, such as proliferation, metastasis, radiotherapy and chemotherapy resistance, metabolism, immunity and inflammation as well as stemness. In this review, we summarize the let-7-dependent and let-7-independent mechanism regulated by Lin28, focusing on its relation with tumor hallmarks in breast cancer, and subsequently discuss our present knowledge of Lin28 to develop a molecular-based therapeutic strategy against breast cancer.

Volume

8

Issue

15

First Page

25721

Last Page

25735

ISSN

1949-2553

Published In/Presented At

Xiong, H., Zhao, W., Wang, J., Seifer, B. J., Ye, C., Chen, Y., Jia, Y., Chen, C., Shen, J., Wang, L., Sui, X., & Zhou, J. (2017). Oncogenic mechanisms of Lin28 in breast cancer: new functions and therapeutic opportunities. Oncotarget, 8(15), 25721–25735. https://doi.org/10.18632/oncotarget.14891

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

28147339

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article