USF-LVHN SELECT
The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum.
Publication/Presentation Date
12-1-2017
Abstract
The FIKK family of kinases is unique to parasites of the Apicomplexan order, which includes all malaria parasites. Plasmodium falciparum, the most virulent form of human malaria, has a family of 19 FIKK kinases, most of which are exported into the host red blood cell during malaria infection. Here, we confirm that FIKK 8 is a non-exported member of the FIKK kinase family. Through expression and purification of the recombinant kinase domain, we establish that emodin is a relatively high-affinity (IC
Volume
75
First Page
217
Last Page
223
ISSN
1090-2120
Published In/Presented At
Lin, B. C., Harris, D. R., Kirkman, L. M. D., Perez, A. M., Qian, Y., Schermerhorn, J. T., Hong, M. Y., Winston, D. S., Xu, L., Lieber, A. M., Hamilton, M., & Brandt, G. S. (2017). The anthraquinone emodin inhibits the non-exported FIKK kinase from Plasmodium falciparum. Bioorganic chemistry, 75, 217–223. https://doi.org/10.1016/j.bioorg.2017.09.011
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
28987877
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article