Clinical doses of radiation reduce collagen matrix stiffness.

Authors

Joseph P Miller
Brandon H Borde
Francois Bordeleau
Matthew R Zanotelli
Danielle J LaValley
Dylan J Parker
Lawrence J Bonassar
Susan C Pannullo
Cynthia A Reinhart-King

Publication/Presentation Date

9-1-2018

Abstract

Cells receive mechanical cues from their extracellular matrix (ECM), which direct migration, differentiation, apoptosis, and in some cases, the transition to a cancerous phenotype. As a result, there has been significant research to develop methods to tune the mechanical properties of the ECM and understand cell-ECM dynamics more deeply. Here, we show that ionizing radiation can reduce the stiffness of an

Volume

2

Issue

3

First Page

031901

Last Page

031901

ISSN

2473-2877

Published In/Presented At

Miller, J. P., Borde, B. H., Bordeleau, F., Zanotelli, M. R., LaValley, D. J., Parker, D. J., Bonassar, L. J., Pannullo, S. C., & Reinhart-King, C. A. (2018). Clinical doses of radiation reduce collagen matrix stiffness. APL bioengineering, 2(3), 031901. https://doi.org/10.1063/1.5018327

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

31069314

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article