USF-LVHN SELECT
Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy.
Publication/Presentation Date
7-1-2017
Abstract
Nanoparticle (NP) chemotherapeutics can improve the therapeutic index of chemoradiotherapy (CRT). However, the effect of NP physical properties, such particle size, on CRT is unknown. To address this, we examined the effects of NP size on biodistribution, efficacy and toxicity in CRT. PEG-PLGA NPs (50, 100, 150 nm mean diameters) encapsulating wotrmannin (wtmn) or KU50019 were formulated. These NP formulations were potent radiosensitizers in vitro in HT29, SW480, and lovo rectal cancer lines. In vivo, the smallest particles avoided hepatic and splenic accumulation while more homogeneously penetrating tumor xenografts than larger particles. However, smaller particles were no more effective in vivo. Instead, there was a trend toward enhanced efficacy with medium sized NPs. The smallest KU60019 particles caused more small bowel toxicity than larger particles. Our results showed that particle size significantly affects nanotherapeutics' biodistrubtion and toxicity but does not support the conclusion that smaller particles are better for this clinical application.
Volume
13
Issue
5
First Page
1673
Last Page
1683
ISSN
1549-9642
Published In/Presented At
Caster, J. M., Yu, S. K., Patel, A. N., Newman, N. J., Lee, Z. J., Warner, S. B., Wagner, K. T., Roche, K. C., Tian, X., Min, Y., & Wang, A. Z. (2017). Effect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy. Nanomedicine : nanotechnology, biology, and medicine, 13(5), 1673–1683. https://doi.org/10.1016/j.nano.2017.03.002
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
28300658
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article