USF-LVHN SELECT
CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function.
Publication/Presentation Date
1-1-2021
Abstract
An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion and shortened persistence. This work led us to hypothesize that by incorporating null mutations of CD28 subdomains (YMNM, PRRP, or PYAP), we could optimize CAR T-cell costimulation and enhance function.
Volume
9
Issue
1
First Page
62
Last Page
74
ISSN
2326-6074
Published In/Presented At
Boucher, J. C., Li, G., Kotani, H., Cabral, M. L., Morrissey, D., Lee, S. B., Spitler, K., Beatty, N. J., Cervantes, E. V., Shrestha, B., Yu, B., Kazi, A., Wang, X., Sebti, S. M., & Davila, M. L. (2021). CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function. Cancer immunology research, 9(1), 62–74. https://doi.org/10.1158/2326-6066.CIR-20-0253
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
33188139
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article