USF-LVHN SELECT
Ocular adverse events following vaccination: overview and update.
Publication/Presentation Date
1-1-2022
Abstract
The Food and Drug Administration has licensed, approved, and expanded guidelines for dozens of vaccines since 2010. Although advancements in biotechnology have made vaccines more effective and safer, none are completely free from adverse effects. Many vaccines have been implicated in causing ocular adverse events based on the temporal association of exposure and putative complication. Determination of causality is difficult. We provide an overview of vaccine side effects and also examine the English literature and the Vaccine Adverse Events Reporting System (VAERS) from 2010 through 2020 for vaccine-implicated ocular adverse events. While reactions of eyelids and conjunctiva are commonly reported, the most frequently implicated serious adverse events are optic neuritis and various patterns of intraocular inflammation. Live attenuated vaccines have the potential to cause ocular infection from vaccine-strain organisms, particularly in those immunosuppressed. While postmarketing registries for suspect vaccination adverse events, such as VAERS, are unable to determine causal associations, they are a mainstay in signaling suspected trends that require investigation. The majority of probable and possible serious ocular adverse effects are distinctly uncommon.
Volume
67
Issue
2
First Page
293
Last Page
306
ISSN
1879-3304
Published In/Presented At
Cheng, J. Y., & Margo, C. E. (2022). Ocular adverse events following vaccination: overview and update. Survey of ophthalmology, 67(2), 293–306. https://doi.org/10.1016/j.survophthal.2021.04.001
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
33865883
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article