Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity

Authors

Sean H Kelly
Benjamin J Cossette
Ajay K Varadhan
Yaoying Wu
Joel H Collier

Publication/Presentation Date

5-10-2021

Abstract

Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-dinucleotides (CDN), can promote sublingual immune responses but must be codelivered with the antigen to the epithelium for maximum effect. We designed peptide-polymer nanofibers (PEG-Q11) displaying nona-arginine (R9) at a high density to promote complexation with CDNs

Volume

7

Issue

5

First Page

1876

Last Page

1888

ISSN

2373-9878

Published In/Presented At

Kelly, S. H., Cossette, B. J., Varadhan, A. K., Wu, Y., & Collier, J. H. (2021). Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization. ACS biomaterials science & engineering, 7(5), 1876–1888. https://doi.org/10.1021/acsbiomaterials.0c01429

Disciplines

Medical Education | Medicine and Health Sciences

PubMedID

33775089

Department(s)

USF-LVHN SELECT Program, USF-LVHN SELECT Program Students

Document Type

Article