USF-LVHN SELECT
Multidisciplinary Management of Primary Urethral Cancer with Radiotherapy.
Publication/Presentation Date
10-1-2023
Abstract
PURPOSE/OBJECTIVE(S): Primary urethral cancer (PUC) is a rare form of genitourinary malignancy with a paucity of data to guide management. We analyzed PUC patients for clinicopathologic characteristics and treatment approach (radiotherapy [RT] with/without consolidative surgery) to identify predictors of outcome and RT response.
MATERIALS/METHODS: We conducted a single-institution retrospective review of patients treated with RT for PUC between 2002 to 2020. Each patient underwent multidisciplinary evaluation (including cystoscopy) as well as imaging to confirm tumor origin in the urethra. The linear quadratic formula was used to calculate the biologically effective dose (BED) using an α/β of 10 for tumor. Descriptive statistics were used to characterize the cohort. Fisher's Exact test was used to compare groups. Time-to-event analyses was conducted with the Kaplan-Meier method; outcomes included overall survival (OS) and time to recurrence (TTR) from diagnosis. Cox regression analysis assessed predictors of outcomes.
RESULTS: A total of 17 patients were identified for analysis. Median age was 63 years (range: 34-86); the majority were female (76.5%) and white (82.4%). Tumors were localized in the proximal (n = 6) or distal (n = 11) urethra. Histology included urothelial (11.8%), squamous (35.3%), adenocarcinoma (29.4%) and mixed (23.5%). Ten patients (58.8%) had cT3 or higher disease with 10 being cN0 (58.8%), 1 cN1 (5.9%), 5 cN2 (29.4%) and 1 cNx (5.9%). Median tumor size was 4.8 cm (range: 0.5-12 cm). The majority (88.2%) were treated with definitive chemoRT with 70.5% receiving platinum therapy. Median RT dose was 59.4 Gy (range: 39.6-70.2) with a median of 30 fractions. One patient underwent upfront cystourethrectomy and 6 (35.3%) underwent consolidative surgery at a median of 2.3 months after RT. Five patients (29.4%) had a complete response (CR) and 70.6% had a partial response (PR) to RT. Of the 7 patients who underwent surgical resection the final pathology was ypTis (28.5%), ypT1 (14.2%), ypT2 (14.2%), ypT4 (28.5%) and pT2 (14.2%). A median of 16 lymph nodes were removed with 1 patient having pN2 and all others pN0. Four patients (66.6%) were downstaged by chemoRT prior to surgery. At a median follow-up time of 8.4 years, the median OS was 37.9 months (range: 23.2-52.7), which was associated with a 5-year OS of 37.2%. Twelve (70.5%) patients recurred with a median TTR of 6.3 months (range 4.8-7.7). No demographics, staging methods, or tumor characteristics were associated with OS or TTR. Urothelial histology was associated with CR following chemoRT (p = 0.02). RT dose (continuous) was associated with OS (p = 0.018) as well as a BED (HR: 0.90, 95% CI: 0.84-0.97; p = 0.01). A BED > 55 Gy was associated with improved median OS (56.4 vs 9.13 months, p = 0.006).
CONCLUSION: Analysis of PUC patients treated with multimodal therapy found higher rates of CR in patients with urothelial histology and increased OS in patients treated with a BED > 55 Gy. Neoadjuvant chemoRT may downstage disease prior to surgical extirpation.
Volume
117
Issue
2S
First Page
431
Last Page
431
ISSN
1879-355X
Published In/Presented At
Retzloff, A., Li, R., Gilbert, S. M., Dohm, A. E., Sexton, W. J., Poch, M., Zemp, L. W., Pow-Sang, J., Jain, R., Chatwal, M. S., Dhillon, J., Yamoah, K., Fernandez, D. C., Johnstone, P. A. S., Spiess, P., & Grass, D. (2023). Multidisciplinary Management of Primary Urethral Cancer with Radiotherapy. International journal of radiation oncology, biology, physics, 117(2S), e431–e432. https://doi.org/10.1016/j.ijrobp.2023.06.1597
Disciplines
Medical Education | Medicine and Health Sciences
PubMedID
37785408
Department(s)
USF-LVHN SELECT Program, USF-LVHN SELECT Program Students
Document Type
Article