Convexity Meningiomas in Patients with Neurofibromatosis Type 2: Long-Term Outcomes After Gamma Knife Radiosurgery.
Publication/Presentation Date
2-1-2021
Abstract
BACKGROUND: Convexity meningiomas are common tumors requiring treatment in patients with neurofibromatosis type 2 (NF2). Although different therapeutic options are described for sporadic convexity meningioma, much less is known about these lesions in patients with NF2 despite their distinct biology and need for multiple treatments. We analyzed the value of Gamma Knife radiosurgery (GKRS) as definitive treatment for convexity meningiomas in patients with NF2.
METHODS: This international multicenter retrospective study was approved by the International Radiosurgery Research Foundation. Patients with NF2 with at least 1 convexity meningioma and 6-month follow-up after primary GKRS were included.
RESULTS: Inclusion criteria were met by 18 patients with NF2. A total of 120 convexity meningiomas (median treatment volume, 0.66 cm
CONCLUSIONS: GKRS is safe and effective as definitive treatment of small to medium-sized convexity meningiomas in patients with NF2. Despite concerns about the particular mutational burden of these tumors, no malignant transformation manifested after treatment. GKRS represents a minimally invasive option that offers long-term tumor control to this specific group of patients.
Volume
146
First Page
678
Last Page
678
ISSN
1878-8769
Published In/Presented At
Ruiz-Garcia, H., Trifiletti, D. M., Mohammed, N., Hung, Y. C., Xu, Z., Chytka, T., Liscak, R., Tripathi, M., Arsanious, D., Cifarelli, C. P., Caceres, M. P., Mathieu, D., Speckter, H., Lekovic, G. P., Mehta, G. U., & Sheehan, J. P. (2021). Convexity Meningiomas in Patients with Neurofibromatosis Type 2: Long-Term Outcomes After Gamma Knife Radiosurgery. World neurosurgery, 146, e678–e684. https://doi.org/10.1016/j.wneu.2020.10.153
Disciplines
Medicine and Health Sciences
PubMedID
33152493
Department(s)
Department of Surgery Faculty
Document Type
Article