Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis.
Publication/Presentation Date
7-15-2001
Abstract
Infection with Campylobacter jejuni serotype HS:19 is associated with the development of Guillain-Barré syndrome (GBS). To determine whether a particular HS:19 clone is associated with GBS, multilocus enzyme electrophoresis (MLEE) was used to analyze a worldwide collection of isolates. There were 34 electropherotypes (ETs) in 3 phylogenetic clusters among 83 C. jejuni isolates. Cluster I contained all HS:19 strains, and a single ET (ET4) accounted for most HS:19 strains. HS:19 strains did not occur in any of the other clusters. ET4 contained isolates from different geographic locations, indicating global spread of this clone. Furthermore, ET4 contained isolates from patients with uncomplicated enteritis and GBS, as well as isolates from animal sources. The results of this study show that HS:19 strains comprise a clonal, although not monomorphic, population, which is distinct from non-HS:19 strains within C. jejuni. A unique clone associated with GBS was not identified by use of MLEE.
Volume
184
Issue
2
First Page
221
Last Page
226
ISSN
0022-1899
Published In/Presented At
Nachamkin, I., Engberg, J., Gutacker, M., Meinersman, R. J., Li, C. Y., Arzate, P., Teeple, E., Fussing, V., Ho, T. W., Asbury, A. K., Griffin, J. W., McKhann, G. M., & Piffaretti, J. C. (2001). Molecular population genetic analysis of Campylobacter jejuni HS:19 associated with Guillain-Barré syndrome and gastroenteritis. The Journal of infectious diseases, 184(2), 221–226. https://doi.org/10.1086/322008
Disciplines
Medicine and Health Sciences
PubMedID
11400077
Department(s)
Department of Pediatrics, Department of Surgery
Document Type
Article