Development of a novel microsampling device to standardize the analysis of intranasal inflammatory biomarkers.
Publication/Presentation Date
3-1-2026
Abstract
Nasal fluid biomarker analysis is an emerging technique for studying sinonasal pathophysiology, monitoring therapeutic efficacy, and discovering novel drug targets. Variability in biomarker results can be contributed to non-standardized collection methodology. To address this, a novel microsampler was developed, designed to enable precise site-specific sampling, consistent volume collection, and high analyte recovery. This study aims to evaluate the performance of this new microsampler device compared to commonly utilized flocked swab, and other absorbent materials. To do so, fixed volumes of a synthetic nasal fluid mimic were deposited onto the anterior region of the inferior turbinate of a 3D-printed sinus model to assess volumetric and collection site accuracy of the nasal microsampler, in comparison to a flocked swab. Additionally, protein biomarker recovery properties of the device's absorption membrane, Leukosorb
Volume
247
First Page
25
Last Page
33
ISSN
1095-9130
Published In/Presented At
Lupancu, T., Limpah, J., Aydin, E., Fan, T., Wong, V., Rimmer, J., Wang, B. S., Yen, D. M., Rostom, E., & Damry, A. M. (2026). Development of a novel microsampling device to standardize the analysis of intranasal inflammatory biomarkers. Methods (San Diego, Calif.), 247, 25–33. https://doi.org/10.1016/j.ymeth.2025.12.006
Disciplines
Medicine and Health Sciences
PubMedID
41421569
Department(s)
Department of Surgery
Document Type
Article