What is the Role of Air Pollution in Chronic Rhinosinusitis?
Publication/Presentation Date
5-1-2020
Abstract
Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder, and several environmental factors may be contributing to disease pathophysiology, including air pollutants. Tobacco smoke and occupational exposures also have been associated with CRS, and environmental exposures may contribute to the variability seen in disease endotype. Animal models that investigate the potential of air pollutants to induce chronic inflammation provide further insight into plausible triggers and modifiers of disease, including contributions to barrier disruption, alterations in the microbiome, and immune dysfunction. Additional studies are needed to further elucidate the role of environmental exposures on CRS pathophysiology and patient outcomes.
Volume
40
Issue
2
First Page
215
Last Page
222
ISSN
1557-8607
Published In/Presented At
Schwarzbach, H. L., Mady, L. J., & Lee, S. E. (2020). What is the Role of Air Pollution in Chronic Rhinosinusitis?. Immunology and allergy clinics of North America, 40(2), 215–222. https://doi.org/10.1016/j.iac.2019.12.011
Disciplines
Medicine and Health Sciences
PubMedID
32278446
Department(s)
Department of Surgery
Document Type
Article