Air pollutants may be environmental risk factors in chronic rhinosinusitis disease progression.

Authors

• Leila J Mady
• Hannah L Schwarzbach
• John A Moore
• Robert M Boudreau
• Sheila Tripathy
• Ellen Kinnee
• Zan M Dodson
• Thomas J Willson
• Jane E Clougherty
• Stella E Lee

Publication/Presentation Date

3-1-2018

Abstract

BACKGROUND: Little is known about the role of environmental exposures in the pathophysiology of chronic rhinosinusitis (CRS). In this study, we measured the impact of air pollutants (particulate matter 2.5 [PM

METHODS: Spatial modeling from pollutant monitoring sites was used to estimate exposures surrounding residences for patients meeting inclusion criteria (total patients, n = 234; CRSsNP, n = 96; CRSwNP, n = 138). Disease severity outcome measures included modified Lund-Mackay score (LMS), systemic steroids, number of functional endoscopic sinus surgeries (FESS), and 22-item Sino-Nasal Outcome Test (SNOT-22) score. PM

RESULTS: Mean PM

CONCLUSION: Air pollutants correlate with CRS symptom severity that may be influenced by exposure levels, with a more pronounced impact on CRSsNP patients. This study is the first to demonstrate the possible role of inhalant pollutants in CRS phenotypes, addressing a critical knowledge gap in environmental risk factors for disease progression.

Volume

8

Issue

3

First Page

377

Last Page

384

ISSN

2042-6984

Published In/Presented At

Mady, L. J., Schwarzbach, H. L., Moore, J. A., Boudreau, R. M., Tripathy, S., Kinnee, E., Dodson, Z. M., Willson, T. J., Clougherty, J. E., & Lee, S. E. (2018). Air pollutants may be environmental risk factors in chronic rhinosinusitis disease progression. International forum of allergy & rhinology, 8(3), 377–384. https://doi.org/10.1002/alr.22052

Disciplines

Medicine and Health Sciences

PubMedID

29210519

Department(s)

Department of Surgery

Document Type

Article