Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer.
Publication/Presentation Date
10-1-2021
Abstract
BACKGROUND: Management of hypopharynx cancer is often extrapolated from larynx cancer. This report analyses treatment patterns and survival limited to hypopharynx cancer using the National Cancer Database (NCDB).
METHODS: There are 9314 patients diagnosed with hypopharynx cancer between 2004 and 2016. The association between treatment modality and survival was analyzed using Kaplan-Meier survival curves and multivariable Cox regression.
RESULTS: Five-year overall survival ranged from 45% for stage I to 21% for stage IVB. Treatment modality did not influence survival in stage I/II. For stage III/IV, chemoradiation and surgery + adjuvant therapy were equivalent. Surgery yielded improved survival for T4 disease. Human papillomavirus (HPV)-positive tumors were present in 21% and were associated with improved hazard ratio of death (0.60, p = < 0.0001).
CONCLUSIONS: Survival is superior for T4 hypopharynx cancer managed with surgery, while treatment modality does not impact outcomes for other T-stages. HPV-positive tumors are associated with improved survival regardless of treatment.
Volume
43
Issue
10
First Page
3042
Last Page
3052
ISSN
1097-0347
Published In/Presented At
Burbure, N., Handorf, E., Ridge, J. A., Bauman, J., Liu, J. C., Giri, A., & Galloway, T. J. (2021). Prognostic significance of human papillomavirus status and treatment modality in hypopharyngeal cancer. Head & neck, 43(10), 3042–3052. https://doi.org/10.1002/hed.26793
Disciplines
Medicine and Health Sciences
PubMedID
34165223
Department(s)
Department of Surgery
Document Type
Article