Peroxiredoxins in Stroke: Friends and Foes.

Authors

• Yingfeng Wan
• Jingwei Zhang
• Liheng Bian
• Xiaoxiao Tan
• Ting Chen
• Guohua Xi
• Ya Hua
• Aditya S Pandey
• Richard F Keep
• Sravanthi Koduri

Publication/Presentation Date

4-2-2026

Abstract

Stroke, a leading cause of mortality and long-term disability, induces complex cascades of oxidative stress and neuroinflammation that exacerbate brain injury. The peroxiredoxin (Prx; Prdx) family, composed of six thiol-dependent antioxidant enzymes (Prx1-6), plays a pivotal role in regulating redox homeostasis and immune responses in the brain. This review synthesizes current knowledge on the isoform-specific roles of Prxs in both ischemic and hemorrhagic stroke, highlighting their dual and context-dependent functions. Intracellular Prxs generally protect neurons and maintain blood-brain barrier (BBB) integrity, while extracellular Prxs-particularly Prx1 and Prx2-act as damage-associated molecular patterns (DAMPs), activating toll-like receptor signaling and amplifying inflammation. Isoforms such as Prx3 and Prx4 exhibit mitochondrial and endothelial protective effects, respectively, whereas Prx6 demonstrates complex roles influenced by its acidic, Ca

Volume

15

Issue

7

ISSN

2073-4409

Published In/Presented At

Wan, Y., Zhang, J., Bian, L., Tan, X., Chen, T., Xi, G., Hua, Y., Pandey, A. S., Keep, R. F., & Koduri, S. (2026). Peroxiredoxins in Stroke: Friends and Foes. Cells, 15(7), 640. https://doi.org/10.3390/cells15070640

Disciplines

Medicine and Health Sciences

PubMedID

41972728

Department(s)

Department of Surgery

Document Type

Article