Hemodynamic characterization of cardiac dysfunction after traumatic brain injury using a controlled cortical impact model in male rats.
Publication/Presentation Date
8-1-2026
Abstract
Traumatic brain injury (TBI) is associated with cardiovascular dysfunction that worsens clinical outcomes, yet the underlying mechanisms are poorly understood. Clinical studies are limited by heterogeneity, highlighting the need for controlled experimental models. Controlled cortical impact (CCI) provides precise control of injury severity, and invasive pressure-volume (PV) loop analysis allows detailed hemodynamic assessment. Adult male Wistar rats underwent sham operation or mild or severe CCI-induced TBI. PV-loop assessment and transthoracic echocardiography were performed at 8 or 24 h after TBI or sham. Serum epinephrine (EPI) and norepinephrine (NE) were quantified by ELISA. At 8 h post-injury, mild TBI was associated with decreased E
Volume
14
Issue
16
First Page
71055
Last Page
71055
ISSN
2051-817X
Published In/Presented At
So, P., Iyengar, A., Weingarten, N., Patel, M., Dominic, J., Belec, A., Ho, J., Shin, S. S., & Atluri, P. (2026). Hemodynamic characterization of cardiac dysfunction after traumatic brain injury using a controlled cortical impact model in male rats. Physiological reports, 14(16), e71055. https://doi.org/10.14814/phy2.71055
Disciplines
Medicine and Health Sciences
PubMedID
42605137
Department(s)
Department of Surgery
Document Type
Article