Pathological Evidence of Necrosis in Recurrent Renal Mass Following Treatment with Sunitinib.
Publication/Presentation Date
12-1-2007
Abstract
Sunitinib is a highly potent, selective vascular endothelial growth factor-receptor types 1 to 3, platelet-derived growth factor (PDGF)-R-alpha, and PDGF-R-ss. Preclinical data suggest that sunitinib (SU11248) has antitumor activity that may result from both inhibition of angiogenesis and direct antiproliferative effects on certain tumor cell types. Sunitinib resulted in tumor shrinkage in 80% of patients who had failed treatment with Bevacizumab and 13% of patients demonstrated an objective Response Evaluation Criteria in solid Tumors (RECIST) in a study presented at the 2006 American Society of Clinical Oncology (ASCO) meeting. We report the first published pathological evidence of sunitinib's effect on recurrent renal cell carcinoma. This was seen in a patient with renal cell carcinoma who developed a renal fossa recurrence 2 years following radical nephrectomy. Tumor shrinkage was evident in the nephrectomy bed after treatment with sunitinib. The pathology of the resected retroperitoneal mass and its implications are discussed.
Volume
14
Issue
12
First Page
1095
Last Page
1097
ISSN
0919-8172
Published In/Presented At
Baccala, A. J., Hedgepeth, R., Kaouk, J., Magi-Galluzzi, C., Gilligan, T., & Fergany, A. (2007). Pathological evidence of necrosis in recurrent renal mass following treatment with sunitinib. International Journal Of Urology: Official Journal Of The Japanese Urological Association, 14(12), 1095-1097.
Disciplines
Medicine and Health Sciences | Other Medical Specialties | Surgery
PubMedID
18036049
Department(s)
Department of Surgery, Department of Surgery Faculty
Document Type
Article