Serum Vascular Endothelial Growth Factor is a Candidate Biomarker of Metastatic Tumor Response to ex vivo Gene Therapy of Renal Cell Cancer.

Publication/Presentation Date

2-1-1998

Abstract

We report the close correlation between changes in serum immunoreactive vascular endothelial growth factor 165 (iVEGF165) levels and metastatic tumor burden measured by computed tomography scan before treatment, during the antitumor response, and during early progression in a patient treated with ex vivo gene therapy for renal cell carcinoma. With the researcher blinded to outcome, iVEGF levels were measured in archived serum samples from a patient with metastatic renal cell carcinoma who demonstrated a 7-month partial remission to treatment with autologous, irradiated human GM-CSF gene transduced tumor vaccine. Although a spontaneous regression could not be formally excluded in this patient, the appearance of 20 new pulmonary metastases on computed tomography scan after nephrectomy and before vaccination indicates that if spontaneous regression occurred, it took place at the start of vaccine treatment.

Volume

51

Issue

2

First Page

327

Last Page

332

ISSN

0090-4295

Disciplines

Medicine and Health Sciences | Other Medical Specialties | Surgery | Urology

PubMedID

9495722

Department(s)

Department of Surgery, Department of Surgery Faculty

Document Type

Article

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