Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme.
Publication/Presentation Date
11-1-2008
Abstract
Glioblastoma multiforme (GBM) is one of the most dreaded cancer diagnoses due to its poor prognosis and the limited treatment options. Homozygous deletion of the p16(INK4a)/p14(ARF)/p15(INK4b) locus is among the most common genetic alterations in GBM. Two recent studies have shown that deletion and mutation of another INK4 family member, p18(INK4c), also drives the pathogenesis of GBM. This minireview will discuss the known roles for p18(INK4c) in the initiation and progression of cancer and suggest opportunities for future studies.
Volume
68
Issue
21
First Page
8657
Last Page
8660
ISSN
1538-7445
Published In/Presented At
Solomon, D. A., Kim, J. S., Jean, W., & Waldman, T. (2008). Conspirators in a capital crime: co-deletion of p18INK4c and p16INK4a/p14ARF/p15INK4b in glioblastoma multiforme. Cancer research, 68(21), 8657–8660. https://doi.org/10.1158/0008-5472.CAN-08-2084
Disciplines
Medicine and Health Sciences
PubMedID
18974105
Department(s)
Department of Surgery
Document Type
Article