Publication/Presentation Date

11-1-2008

Abstract

Glioblastoma multiforme (GBM) is one of the most dreaded cancer diagnoses due to its poor prognosis and the limited treatment options. Homozygous deletion of the p16(INK4a)/p14(ARF)/p15(INK4b) locus is among the most common genetic alterations in GBM. Two recent studies have shown that deletion and mutation of another INK4 family member, p18(INK4c), also drives the pathogenesis of GBM. This minireview will discuss the known roles for p18(INK4c) in the initiation and progression of cancer and suggest opportunities for future studies.

Volume

68

Issue

21

First Page

8657

Last Page

8660

ISSN

1538-7445

Disciplines

Medicine and Health Sciences

PubMedID

18974105

Department(s)

Department of Surgery

Document Type

Article

Share

COinS