Perichondrium directed cartilage formation in silk fibroin and chitosan blend scaffolds for tracheal transplantation.
Publication/Presentation Date
9-1-2011
Abstract
The purpose of this study was to investigate the potential of silk fibroin and chitosan blend (SFCS) biological scaffolds for the purpose of cartilage tissue engineering with applications in tracheal tissue reconstruction. The capability of these scaffolds as cell carrier systems for chondrocytes was determined in vitro and cartilage generation in vivo on engineered chondrocyte-scaffold constructs with and without a perichondrium wrapping was tested in an in vivo nude mouse model. SFCS scaffolds supported chondrocyte adhesion, proliferation, and differentiation, determined as features of the cells based on the spherical cell morphology, increased accumulation of glycosaminoglycans, and increased collagen type II deposition with time within the scaffold framework. Perichondrium wrapping significantly (P
Volume
7
Issue
9
First Page
3422
Last Page
3431
ISSN
1878-7568
Published In/Presented At
Zang, M., Zhang, Q., Davis, G., Huang, G., Jaffari, M., Ríos, C. N., Gupta, V., Yu, P., & Mathur, A. B. (2011). Perichondrium directed cartilage formation in silk fibroin and chitosan blend scaffolds for tracheal transplantation. Acta biomaterialia, 7(9), 3422–3431. https://doi.org/10.1016/j.actbio.2011.05.012
Disciplines
Medicine and Health Sciences
PubMedID
21640205
Department(s)
Department of Surgery
Document Type
Article