Use of Integra for Reconstruction after Nevi Resection: A Systematic Review and Pooled Analysis of Reported Cases.
Publication/Presentation Date
1-1-2019
Abstract
BACKGROUND: The use of Integra Dermal Reconstruction Template has emerged as an option for wound reconstruction, after resection of congenital nevi, especially giant congenital nevi. There have been many reports on Integra use in the literature for this purpose. This systematic review with pooled analysis examines the current literature regarding Integra use after resection of congenital nevi, including patient characteristics and reported outcomes.
METHODS: Systematic electronic searches were performed using PubMed, Ovid, Embase, and Cochrane library databases for studies reporting the use of Integra to reconstruct defects after nevi resection. Studies were analyzed if they met the inclusion criteria. Pooled descriptive statistics were performed.
RESULTS: Thirteen studies that met the inclusion criteria were included for analysis, yielding 31 procedures in 31 patients. Eleven of the thirteen studies were case reports representing 17 of the 31 patients. One study was retrospective, and the other study was a prospective study. The mean follow-up was 2.67 years (range, 0.2-13 years). The overall wound closure rate was 100%. The overall initial Integra take rate was 90.3% and the skin graft take rate was 100%. The rate of reported complications was 14.8%. The average age of patients was 7.36 years. The average size of the nevus was 6.29% TBSA (range, 0.005%-26%), and the time to definitive skin grafting was 3.28 weeks. Significant heterogeneity was found among the published studies.
CONCLUSION: We conclude that the use of Integra appears to be a safe and viable option for defect reconstruction after the primary or secondary excision of congenital nevi of different sizes and on most parts of the body. Long-term follow-up studies and prospective cohort studies are required in order to fully estimate the incidence of complications. However, the rarity of this condition make these types of studies very difficult.
Volume
2019
First Page
9483627
Last Page
9483627
ISSN
2356-7759
Published In/Presented At
Opoku-Agyeman, J., Humenansky, K., Davis, W., 3rd, & Glat, P. (2019). Use of Integra for Reconstruction after Nevi Resection: A Systematic Review and Pooled Analysis of Reported Cases. Surgery research and practice, 2019, 9483627. https://doi.org/10.1155/2019/9483627
Disciplines
Medicine and Health Sciences
PubMedID
31687472
Department(s)
Department of Surgery, Department of Pediatrics
Document Type
Article