Pregnancy After Lung Transplant
Publication/Presentation Date
6-1-2012
Abstract
The purpose of this study was to analyze pregnancy outcomes in female lung transplant recipients. Data were collected from the National Transplantation Pregnancy Registry via questionnaires, interviews, and hospital records. Twenty-one female lung recipients reported 30 pregnancies with 32 outcomes (1 triplet pregnancy). Outcomes included 18 live births, 5 therapeutic abortions, and 9 spontaneous abortions. No stillbirths or ectopic pregnancies were reported. Mean (SD) interval from transplant to conception was 3.6 (3.3) years (range, 0.1-11.3 years). Comorbid conditions during pregnancy included hypertension in 16, infections in 7, diabetes in 7, preeclampsia in 1, and rejection in 5 women. Ten of the 21 recipients received a transplant because of cystic fibrosis and accounted for 12 pregnancy outcomes (7 live births, 3 spontaneous abortions, and 2 therapeutic abortions). At last recipient contact, 13 had adequate function, 2 had reduced function, 5 recipients had died (2 with cystic fibrosis), and 1 recipient had a nonfunctioning transplant. Mean gestational age of the newborn was 33.9 (SD, 5.2) weeks, and 11 were born preterm (weeks). Mean birthweight was 2206 (SD, 936) g and 11 were low birthweight (g). Two neonatal deaths were associated with a triplet pregnancy; one fetus spontaneously aborted at 14 weeks and 2 died after preterm birth at 22 weeks. At last follow-up, all 16 surviving children were reported healthy and developing well. Successful pregnancy is possible after lung transplant, even among recipients with a diagnosis of cystic fibrosis.
Volume
22
Issue
2
First Page
134
Last Page
140
ISSN
1526-9248
Published In/Presented At
Shaner, J., Coscia, L., Constantinescu, S., McGrory, C., Doria, C., Moritz, M., & ... Cowan, S. (2012). Pregnancy after lung transplant. Progress In Transplantation (Aliso Viejo, Calif.), 22(2), 134-140. doi:10.7182/pit2012285
Disciplines
Circulatory and Respiratory Physiology | Medical Sciences | Medical Specialties | Medicine and Health Sciences | Other Medical Specialties | Surgery
PubMedID
22878069
LVHN link
http://search.ebscohost.com/login.aspx?direct=true&db=mnh&AN=22878069&site=ehost-live&scope=site
Peer Reviewed for front end display
Peer-Reviewed
Department(s)
Department of Surgery, Department of Surgery Faculty
Document Type
Article