Local manganese chloride treatment accelerates fracture healing in a rat model.
Publication/Presentation Date
1-1-2015
Abstract
This study investigated the effects of local delivery of manganese chloride (MnCl2), an insulin-mimetic compound, upon fracture healing using a rat femoral fracture model. Mechanical testing, histomorphometry, and immunohistochemistry were performed to assess early and late parameters of fracture healing. At 4 weeks post-fracture, maximum torque to failure was 70% higher (P
Volume
33
Issue
1
First Page
122
Last Page
130
ISSN
1554-527X
Published In/Presented At
Hreha, J., Wey, A., Cunningham, C., Krell, E. S., Brietbart, E. A., Paglia, D. N., Montemurro, N. J., Nguyen, D. A., Lee, Y. J., Komlos, D., Lim, E., Benevenia, J., O'Connor, J. P., & Lin, S. S. (2015). Local manganese chloride treatment accelerates fracture healing in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 122–130. https://doi.org/10.1002/jor.22733
Disciplines
Medicine and Health Sciences
PubMedID
25231276
Department(s)
Department of Surgery
Document Type
Article