Local manganese chloride treatment accelerates fracture healing in a rat model.
This study investigated the effects of local delivery of manganese chloride (MnCl2), an insulin-mimetic compound, upon fracture healing using a rat femoral fracture model. Mechanical testing, histomorphometry, and immunohistochemistry were performed to assess early and late parameters of fracture healing. At 4 weeks post-fracture, maximum torque to failure was 70% higher (P
Published In/Presented At
Hreha, J., Wey, A., Cunningham, C., Krell, E. S., Brietbart, E. A., Paglia, D. N., Montemurro, N. J., Nguyen, D. A., Lee, Y. J., Komlos, D., Lim, E., Benevenia, J., O'Connor, J. P., & Lin, S. S. (2015). Local manganese chloride treatment accelerates fracture healing in a rat model. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 33(1), 122–130. https://doi.org/10.1002/jor.22733
Medicine and Health Sciences
Department of Surgery