Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome.
Publication/Presentation Date
1-1-2022
Abstract
Previous studies have suggested that girls with Turner syndrome (TS) exhibit symptoms of social anxiety during interactions with others. However, few studies have quantified these behaviors during naturalistic face-to-face social encounters. In this study, we coded observational markers of social anxiety in prepubertal girls with TS and age-matched controls during a 10-min social encounter with an unfamiliar examiner. Results showed that girls with TS exhibited significantly higher levels of gaze avoidance compared to controls. Impairments in social gaze were particularly increased in girls with a maternally retained X chromosome (Xm), suggesting a genomic imprinting effect. These data indicate that social gaze avoidance may be a critical behavioral marker for identifying early social dysfunction in young girls with TS.
Volume
52
Issue
1
First Page
16
Last Page
27
ISSN
1573-3432
Published In/Presented At
Hall, S. S., Riley, M. J., Weston, R. N., Lepage, J. F., Hong, D. S., Jo, B., Hallmayer, J., & Reiss, A. L. (2022). Effects of X Chromosome Monosomy and Genomic Imprinting on Observational Markers of Social Anxiety in Prepubertal Girls with Turner Syndrome. Journal of autism and developmental disorders, 52(1), 16–27. https://doi.org/10.1007/s10803-021-04896-y
Disciplines
Medicine and Health Sciences
PubMedID
33751331
Department(s)
Department of Pediatrics, Department of Surgery
Document Type
Article